Ontology highlight
ABSTRACT:
SUBMITTER: Ranjbar S
PROVIDER: S-EPMC6909047 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ranjbar Shahin S Haridas Viraga V Nambu Aya A Jasenosky Luke D LD Sadhukhan Supriya S Ebert Thomas S TS Hornung Veit V Cassell Gail H GH Falvo James V JV Goldfeld Anne E AE
iScience 20191106
To establish stable infection, Mycobacterium tuberculosis (MTb) must overcome host innate immune mechanisms, including those that sense pathogen-derived nucleic acids. Here, we show that the host cytosolic RNA sensing molecules RIG-I-like receptor (RLR) signaling proteins RIG-I and MDA5, their common adaptor protein MAVS, and the RNA-dependent kinase PKR each independently inhibit MTb growth in human cells. Furthermore, we show that MTb broadly stimulates RIG-I, MDA5, MAVS, and PKR gene expressi ...[more]