Ontology highlight
ABSTRACT:
SUBMITTER: Kurata M
PROVIDER: S-EPMC6909097 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Kurata Masashi M Fujiwara Naoko N Fujita Ken-Ichi KI Yamanaka Yasutaka Y Seno Shigeto S Kobayashi Hisato H Miyamae Yusaku Y Takahashi Nobuyuki N Shibuya Yasuyuki Y Masuda Seiji S
iScience 20191120
Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind to mRNA splicing-related proteins to induce a widespread change of splicing patterns in treated cells. Their inhibitory activity on splicing is relatively moderate, and introns with weak splice sites tend to be sensitive to them. Such introns remain un ...[more]