Ontology highlight
ABSTRACT:
SUBMITTER: Schmitthenner HF
PROVIDER: S-EPMC6910127 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Schmitthenner Hans F HF Dobson Damien E DE Jones Kelsea G KG Akporji Nnamdi N Soika Dana Q M DQM Nastiuk Kent L KL Hornak Joseph P JP
Chemistry (Weinheim an der Bergstrasse, Germany) 20190924 61
A practical, convergent synthesis of prostate-specific membrane antigen (PSMA) targeted imaging agents for MRI, PET, and SPECT of prostate cancer has been developed. In this approach, metals chelated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were placed on the side chains of lysine early in the synthesis to form imaging modules. These are coupled to targeting modules, in this case consisting of the PSMA-binding urea DCL, bonded to an activated linker. The modular approac ...[more]