Ontology highlight
ABSTRACT:
SUBMITTER: Scherm MG
PROVIDER: S-EPMC6910913 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nature communications 20191213 1
In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poorly understood. Here, we show that during islet autoimmunity an miR142-3p/Tet2/Foxp3 axis interferes with the efficient induction of regulatory T (Treg) cells, resulting in impaired Treg stability in m ...[more]