Ontology highlight
ABSTRACT:
SUBMITTER: Doebbeler M
PROVIDER: S-EPMC6124443 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Doebbeler Marina M Koenig Christina C Krzyzak Lena L Seitz Christine C Wild Andreas A Ulas Thomas T Baßler Kevin K Kopelyanskiy Dmitry D Butterhof Alina A Kuhnt Christine C Kreiser Simon S Stich Lena L Zinser Elisabeth E Knippertz Ilka I Wirtz Stefan S Riegel Christin C Hoffmann Petra P Edinger Matthias M Nitschke Lars L Winkler Thomas T Schultze Joachim L JL Steinkasserer Alexander A Lechmann Matthias M
JCI insight 20180607 11
Foxp3-positive regulatory T cells (Tregs) are crucial for the maintenance of immune homeostasis and keep immune responses in check. Upon activation, Tregs are transferred into an effector state expressing transcripts essential for their suppressive activity, migration, and survival. However, it is not completely understood how different intrinsic and environmental factors control differentiation. Here, we present for the first time to our knowledge data suggesting that Treg-intrinsic expression ...[more]