Ontology highlight
ABSTRACT:
SUBMITTER: Chakraborty S
PROVIDER: S-EPMC6911056 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chakraborty Samarpana S Dakle Pushkar P Sinha Anirban A Vishweswaraiah Sangeetha S Nagori Aditya A Salimath Shivalingaswamy S Prakash Y S YS Lodha R R Kabra S K SK Ghosh Balaram B Faruq Mohammed M Mahesh P A PA Agrawal Anurag A
Scientific reports 20191213 1
It is estimated from twin studies that heritable factors account for at-least half of asthma-risk, of which genetic variants identified through population studies explain only a small fraction. Multi-generation large families with high asthma prevalence can serve as a model to identify highly penetrant genetic variants in closely related individuals that are missed by population studies. To achieve this, a four-generation Indian family with asthma was identified and recruited for examination and ...[more]