Ontology highlight
ABSTRACT:
SUBMITTER: Celiku O
PROVIDER: S-EPMC6911112 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Celiku Orieta O Gilbert Mark R MR Lavi Orit O
Nature communications 20191213 1
Glioblastoma (GBM) is an aggressive type of brain cancer with remarkable cell migration and adaptation capabilities. Exploratory adaptation-utilization of random changes in gene regulation for adaptive benefits-was recently proposed as the process enabling organisms to survive unforeseen conditions. We investigate whether exploratory adaption explains how GBM cells from different anatomic regions of the tumor cope with micro-environmental pressures. We introduce new notions of phenotype and phen ...[more]