Templated construction of a Zn-selective protein dimerization motif.
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ABSTRACT:
SUBMITTER: Salgado EN
PROVIDER: S-EPMC6911222 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Templated construction of a Zn-selective protein dimerization motif.
Salgado Eric N EN Brodin Jeffrey D JD To Magnus M MM Tezcan F Akif FA
Inorganic chemistry 20110607 13
Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that i ...[more]
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