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Overview of microRNA-199a Regulation in Cancer.


ABSTRACT: microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6911337 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Overview of microRNA-199a Regulation in Cancer.

Wang Qiwen Q   Ye Bingyu B   Wang Ping P   Yao Fenjie F   Zhang Chunyan C   Yu Guoying G  

Cancer management and research 20191210


microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR  ...[more]

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