Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann UAT
PROVIDER: S-EPMC6911978 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Hofmann Urs A T UAT Fabritius Arne A Rebling Johannes J Estrada Héctor H Deán-Ben X Luís XL Griesbeck Oliver O Razansky Daniel D
iScience 20191125
Functional optoacoustic (OA) imaging assisted with genetically encoded calcium ion indicators (GECIs) holds promise for imaging large-scale neuronal activity at depths and spatiotemporal resolutions not attainable with existing optical microscopic techniques. However, currently available GECIs optimized for fluorescence (FL) imaging lack sufficient contrast for OA imaging and respond at wavelengths having limited penetration into the mammalian brain. Here we present an imaging platform capable o ...[more]