Ontology highlight
ABSTRACT:
SUBMITTER: Laks E
PROVIDER: S-EPMC6912164 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Laks Emma E McPherson Andrew A Zahn Hans H Lai Daniel D Steif Adi A Brimhall Jazmine J Biele Justina J Wang Beixi B Masud Tehmina T Ting Jerome J Grewal Diljot D Nielsen Cydney C Leung Samantha S Bojilova Viktoria V Smith Maia M Golovko Oleg O Poon Steven S Eirew Peter P Kabeer Farhia F Ruiz de Algara Teresa T Lee So Ra SR Taghiyar M Jafar MJ Huebner Curtis C Ngo Jessica J Chan Tim T Vatrt-Watts Spencer S Walters Pascale P Abrar Nafis N Chan Sophia S Wiens Matt M Martin Lauren L Scott R Wilder RW Underhill T Michael TM Chavez Elizabeth E Steidl Christian C Da Costa Daniel D Ma Yussanne Y Coope Robin J N RJN Corbett Richard R Pleasance Stephen S Moore Richard R Mungall Andrew J AJ Mar Colin C Cafferty Fergus F Gelmon Karen K Chia Stephen S Marra Marco A MA Hansen Carl C Shah Sohrab P SP Aparicio Samuel S
Cell 20191101 5
Accurate measurement of clonal genotypes, mutational processes, and replication states from individual tumor-cell genomes will facilitate improved understanding of tumor evolution. We have developed DLP+, a scalable single-cell whole-genome sequencing platform implemented using commodity instruments, image-based object recognition, and open source computational methods. Using DLP+, we have generated a resource of 51,926 single-cell genomes and matched cell images from diverse cell types includin ...[more]