Ontology highlight
ABSTRACT:
SUBMITTER: Wilson AM
PROVIDER: S-EPMC6914268 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Wilson Alyssa Michelle AM Schalek Richard R Suissa-Peleg Adi A Jones Thouis R TR Knowles-Barley Seymour S Pfister Hanspeter H Lichtman Jeff William JW
Cell reports 20191101 9
During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood. To get insight about the processes responsible for this remapping, we reconstructed serial electron microscopy datasets from mice during the first postnatal week. Between days 3 and 7, individual climbing fibers selectively add many synapses onto a subset of Purkinje targets in a positive-feedback manner, w ...[more]