Ontology highlight
ABSTRACT:
SUBMITTER: Bosman LW
PROVIDER: S-EPMC3303929 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Bosman Laurens W J LW Hartmann Jana J Barski Jaroslaw J JJ Lepier Alexandra A Noll-Hussong Michael M Reichardt Louis F LF Konnerth Arthur A
Brain cell biology 20060201 1
The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity-dependent synaptic strengthening in the central nervous system. These TrkB-mediated actions occur in a highly cell-type specific manner. Here we report that cerebellar Purkinje cells, which are richly endowed with TrkB receptors, develop a normal morphology in trkB-deficient mice. Thus, in contrast to other types of ...[more]