Ontology highlight
ABSTRACT:
SUBMITTER: Treff NR
PROVIDER: S-EPMC6915076 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Treff Nathan R NR Eccles Jennifer J Lello Lou L Bechor Elan E Hsu Jeffrey J Plunkett Kathryn K Zimmerman Raymond R Rana Bhavini B Samoilenko Artem A Hsu Steven S Tellier Laurent C A M LCAM
Frontiers in endocrinology 20191204
For over 2 decades preimplantation genetic testing (PGT) has been in clinical use to reduce the risk of miscarriage and genetic disease in patients with advanced maternal age and risk of transmitting disease. Recently developed methods of genome-wide genotyping and machine learning algorithms now offer the ability to genotype embryos for polygenic disease risk with accuracy equivalent to adults. In addition, contemporary studies on adults indicate the ability to predict polygenic disorders with ...[more]