Ontology highlight
ABSTRACT:
SUBMITTER: Karavani E
PROVIDER: S-EPMC6957074 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Karavani Ehud E Zuk Or O Zeevi Danny D Barzilai Nir N Stefanis Nikos C NC Hatzimanolis Alex A Smyrnis Nikolaos N Avramopoulos Dimitrios D Kruglyak Leonid L Atzmon Gil G Lam Max M Lencz Todd T Carmi Shai S
Cell 20191121 6
The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which undermines discussion of associated ethical concerns. Here, we use theory, simulations, and real data to evaluate the potential gain of embryo screening, defined as the difference in tr ...[more]