Long segment 3D double inversion recovery (DIR) hypersignal on MRI in glaucomatous optic neuropathy.

ABSTRACT: BACKGROUND:In this retrospective study the relationship between intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness and pathologic hypersignal in optic nerve segments on 3D double inversion recovery (DIR) MR sequence in 21 patients with proven glaucoma of different origin was evaluated. METHODS:All patients were examined on a 3?T MR Philips® scanner. Pathologic optic nerve DIR hypersignal was determined in four different nerve segments. IOP was measured in mmHg by applanation tonometry. RNFL thickness was measured in ?m with optical coherence tomography (OCT Heidelberg Engineering Spectralis® apparatus). Wilcoxon rank sum tests, student's t-tests and (multivariate) linear regression models were appied. RESULTS:3D DIR hypersignal was present in 17 (41.5%) optic nerves. 3D DIR hypersignal was not related to ischemic or demyelinating optic nerve pathology but was associated with increased IOP (19.8 [24-18]; versus 15.45; [18.85-13.75] mmHg; p?=?0.008) and decreased RNFL thickness (61.06?±?12.1 versus 82.5?±?21.6??m; p?

SUBMITTER: Sartoretti T 

PROVIDER: S-EPMC6916010 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature