Ontology highlight
ABSTRACT:
SUBMITTER: Griffith EC
PROVIDER: S-EPMC6916429 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Griffith Elizabeth C EC Zhao Ying Y Singh Aman P AP Conlon Brian P BP Tangallapally Rajendra R Shadrick William R WR Liu Jiuyu J Wallace Miranda J MJ Yang Lei L Elmore John M JM Li Yong Y Zheng Zhong Z Miller Darcie J DJ Cheramie Martin N MN Lee Robin B RB LaFleur Michael D MD Lewis Kim K Lee Richard E RE
ACS infectious diseases 20191024 11
Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill nongrowing bacteria represents a new opportunity to combat deep-seated biofilm infections. However, the acyldepsipeptide scaffold is subject to rapid metabolism. Herein, we explore alteration of the potentially metabolically reactive α,β unsaturated acyl chain. Through targeted synthesis, a new class of pheny ...[more]