Dataset Information

A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment.

ABSTRACT: BACKGROUND:Stress has been known to increase craving in individuals with Alcohol Use Disorders (AUD) and predict future alcohol relapse risk, but whether stress on a particular day affects craving on that day to impact prospective alcohol intake in the real world, particularly during early treatment and recovery, has not been studied thus far. METHOD:The first study included 85 AUD individuals who reported their daily stress, craving, and alcohol intake in the first two weeks of early treatment. A second validation study included 28 AUD patients monitored daily during eight weeks of outpatient 12-Step based behavioral counseling treatment for AUD. Data were collected from telephone-based daily diaries for 903 days in Study 1 and 1488 in Study 2. Multilevel latent models tested if daily and person-averaged craving mediated the link between stressful events and next day drinking during treatment. RESULTS:In both Study 1 and 2, exposure to a stressful event on a particular day predicted increased craving on that day (p's?.002); and such increases in craving predicted the likelihood of drinking the next day (p's?.014) and the drinking amount (p's

SUBMITTER: Wemm SE

PROVIDER: S-EPMC6916671 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment.

Wemm Stephanie E SE Larkin Chloe C Hermes Gretchen G Tennen Howard H Sinha Rajita R

Drug and alcohol dependence 20190920

<h4>Background</h4>Stress has been known to increase craving in individuals with Alcohol Use Disorders (AUD) and predict future alcohol relapse risk, but whether stress on a particular day affects craving on that day to impact prospective alcohol intake in the real world, particularly during early treatment and recovery, has not been studied thus far.<h4>Method</h4>The first study included 85 AUD individuals who reported their daily stress, craving, and alcohol intake in the first two weeks of e ...[more]

PMID: 31574406

Similar Datasets

Project description:Background and aimsIncreasing evidence suggests that a ketogenic (high-fat, low-carbohydrate) diet (KD) intervention reduces alcohol withdrawal severity and alcohol craving in individuals with alcohol use disorder (AUD) by shifting brain energetics from glucose to ketones. We hypothesized that the KD would reduce a neurobiological craving signature when individuals undergoing alcohol detoxification treatment were exposed to alcohol cues.MethodsWe performed a secondary analysis of functional magnetic resonance data of 33 adults with an AUD who were randomized to a KD (n = 19) or a standard American diet (SA; n = 14) and underwent 3 weeks of inpatient alcohol detoxification treatment. Once per week, participants performed an alcohol cue-reactivity paradigm with functional magnetic resonance imaging. We extracted brain responses to food and alcohol cues and quantified the degree to which each set of brain images shared a pattern of activation with a recently established 'Neurobiological Craving Signature' (NCS). We then performed a group-by-time repeated measures ANOVA to test for differences in craving signature expression between the dietary groups over the three-week treatment period. We also correlated these expression patterns with self-reported wanting ratings for alcohol cues.ResultsFor alcohol relative to food cues, there was a main effect of group, such that the KD group showed lower NCS expression across all 3 weeks of treatment. The main effect of time and the group-by-time interaction were not significant. Self-reported wanting for alcohol cues reduced with KD compared to SA but did not correlate with the NCS score.ConclusionA ketogenic diet reduces self-reported alcohol wanting, and induced lower NCS to alcohol cues during inpatient treatment for AUD. However, in the KD group alcohol wanting continued to decrease across the 3 weeks of abstinence while the NCS scores remained stable, suggesting that this cue-induced NCS may not fully capture ongoing, non-cue-induced alcohol desire.

Dataset Information

A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment.

Publications

A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets