Ontology highlight
ABSTRACT:
SUBMITTER: Chen AJ
PROVIDER: S-EPMC6916744 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chen Andy J AJ Huang Kai-Chih KC Bopp Selina S Summers Robert R Dong Puting P Huang Yimin Y Zong Cheng C Wirth Dyann D Cheng Ji-Xin JX
Journal of biomedical optics 20191201 1
Hemozoin, the heme detoxification end product in malaria parasites during their growth in the red blood cells (RBCs), serves as an important marker for diagnosis and treatment target of malaria disease. However, the current method for hemozoin-targeted drug screening mainly relies on <i>in vitro</i> β-hematin inhibition assays, which may lead to false-positive events due to under-representation of the real hemozoin crystal. Quantitative <i>in situ</i> imaging of hemozoin is highly desired for hi ...[more]