Ontology highlight
ABSTRACT:
SUBMITTER: Luo H
PROVIDER: S-EPMC6917035 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Luo Huacheng H Zhu Ganqian G Xu Jianfeng J Lai Qian Q Yan Bowen B Guo Ying Y Fung Tsz Kan TK Zeisig Bernd B BB Cui Ya Y Zha Jie J Cogle Christopher C Wang Fei F Xu Bing B Yang Feng-Chun FC Li Wei W So Chi Wai Eric CWE Qiu Yi Y Xu Mingjiang M Huang Suming S
Cancer cell 20191127 6
Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is aberrantly activated in acute myeloid leukemia (AML) to alter HOXA-driven topologically associated domain (TAD) and gene expression. HOTTIP loss attenuates leukemogenesis of transplanted mice, while reac ...[more]