Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC6917491 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Xu Juncao J Cui Kaijie K Shen Liqiang L Shi Jing J Li Lingting L You Linlin L Fang Chengli C Zhao Guoping G Feng Yu Y Yang Bei B Zhang Yu Y
eLife 20191217
σ<sup>S</sup> is a master transcription initiation factor that protects bacterial cells from various harmful environmental stresses including antibiotic pressure. Although its mechanism remains unclear, it is known that full activation of σ<sup>S</sup>-mediated transcription requires a σ<sup>S</sup>-specific activator, Crl. In this study, we determined a 3.80 Å cryo-EM structure of an <i>Escherichia coli</i> transcription activation complex (<i>E. coli</i> Crl-TAC) comprising <i>E. coli</i> σ<su ...[more]