Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants.

ABSTRACT: OBJECTIVE:To evaluate the association of ibuprofen exposure with the risk of bronchopulmonary dysplasia (BPD) in extremely premature infants. STUDY DESIGN:This was a retrospective study of all extremely premature infants admitted to a tertiary unit from 2016 to 2018. RESULTS:A total of 203 extremely premature infants were included in this study. The rate of BPD was significantly higher in infants with early exposure to ibuprofen (42.5%) compared to infants with no exposure (21.6%, P?=?0.001). After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p?=?0.016). Further analysis showed a trend towards higher risk of BPD in infants with successful patent ductus arteriosus (PDA) closure after ibuprofen treatment (32.3%) compared to non-treated infants (20.2%, p?=?0.162). CONCLUSION:Our findings suggest that ibuprofen exposure may contribute to the occurrence of BPD in extremely preterm infants.

SUBMITTER: Chen X 

PROVIDER: S-EPMC6917570 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature