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Gibbs free energy of protein-protein interactions correlates with ATP production in cancer cells.

ABSTRACT: In this paper, we analyze several cancer cell types from two seemingly independent angles: (a) the over-expression of various proteins participating in protein-protein interaction networks and (b) a metabolic shift from oxidative phosphorylation to glycolysis. We use large data sets to obtain a thermodynamic measure of the protein-protein interaction network, namely the associated Gibbs free energy. We find a strong inverse correlation between the percentage of energy production via oxidative phosphorylation and the Gibbs free energy of the protein networks. The latter is a measure of functional dysregulation within the cell. Our findings corroborate earlier indications that signaling pathway upregulation in cancer cells is linked to the metabolic shift known as the Warburg effect; hence, these two seemingly independent characteristics of cancer phenotype may be interconnected.

SUBMITTER: Golas SM

PROVIDER: S-EPMC6917683 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Gibbs free energy of protein-protein interactions correlates with ATP production in cancer cells.

Golas Stefan M SM Nguyen Amber N AN Rietman Edward A EA Tuszynski Jack A JA

Journal of biological physics 20191216 4

In this paper, we analyze several cancer cell types from two seemingly independent angles: (a) the over-expression of various proteins participating in protein-protein interaction networks and (b) a metabolic shift from oxidative phosphorylation to glycolysis. We use large data sets to obtain a thermodynamic measure of the protein-protein interaction network, namely the associated Gibbs free energy. We find a strong inverse correlation between the percentage of energy production via oxidative ph ...[more]

PMID: 31845118

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