Ontology highlight
ABSTRACT:
SUBMITTER: Navarro-Munoz JC
PROVIDER: S-EPMC6917865 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Navarro-Muñoz Jorge C JC Selem-Mojica Nelly N Mullowney Michael W MW Kautsar Satria A SA Tryon James H JH Parkinson Elizabeth I EI De Los Santos Emmanuel L C ELC Yeong Marley M Cruz-Morales Pablo P Abubucker Sahar S Roeters Arne A Lokhorst Wouter W Fernandez-Guerra Antonio A Cappelini Luciana Teresa Dias LTD Goering Anthony W AW Thomson Regan J RJ Metcalf William W WW Kelleher Neil L NL Barona-Gomez Francisco F Medema Marnix H MH
Nature chemical biology 20191125 1
Genome mining has become a key technology to exploit natural product diversity. Although initially performed on a single-genome basis, the process is now being scaled up to mine entire genera, strain collections and microbiomes. However, no bioinformatic framework is currently available for effectively analyzing datasets of this size and complexity. In the present study, a streamlined computational workflow is provided, consisting of two new software tools: the 'biosynthetic gene similarity clus ...[more]