Ontology highlight
ABSTRACT:
SUBMITTER: Ogasawara N
PROVIDER: S-EPMC6917894 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ogasawara Noriko N Poposki Julie A JA Klingler Aiko I AI Tan Bruce K BK Hulse Kathryn E KE Stevens Whitney W WW Peters Anju T AT Grammer Leslie C LC Welch Kevin C KC Smith Stephanie S SS Conley David B DB Raviv Joseph R JR Soroosh Pejman P Takano Ken-Ichi KI Himi Tetsuo T Kern Robert C RC Schleimer Robert P RP Kato Atsushi A
Mucosal immunology 20191022 1
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 inflammation with accumulation of activated group 2 innate lymphoid cells (ILC2s) and elevation of thymic stromal lymphopoietin (TSLP). A member of the TNF superfamily (TNFSF), TNFSF15, is known to induce the production of type 2 cytokines in ILC2s. Although ILC2s have been implicated in CRSwNP, the presence and role of TNFSFs in ILC2-mediated type 2 inflammation in CRSwNP has not been elucidated. Here, we investigate t ...[more]