Ontology highlight
ABSTRACT:
SUBMITTER: George MR
PROVIDER: S-EPMC6918742 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
George Matthew R MR Duan Qiming Q Nagle Abigail A Kathiriya Irfan S IS Huang Yu Y Rao Kavitha K Haldar Saptarsi M SM Bruneau Benoit G BG
Development (Cambridge, England) 20191209 23
Long intergenic non-coding RNAs (lincRNAs) have been implicated in gene regulation, but their requirement for development needs empirical interrogation. We computationally identified nine murine lincRNAs that have developmentally regulated transcriptional and epigenomic profiles specific to early heart differentiation. Six of the nine lincRNAs had <i>in vivo</i> expression patterns supporting a potential function in heart development, including a transcript downstream of the cardiac transcriptio ...[more]