Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking.
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ABSTRACT:
SUBMITTER: Vazquez M
PROVIDER: S-EPMC6919190 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking.
Vazquez Maribel M Frazier Jessica H JH Reichel Carmela M CM Peters Jamie J
Learning & memory (Cold Spring Harbor, N.Y.) 20191216 1
Females are at higher risk for certain opioid addictive behaviors, but the influence of ovarian hormones is unknown. In our rat model of heroin self-administration, females exhibited higher relapse rates that correlated with rates of heroin seeking on the first extinction session. We administered estradiol alone, or in combination with progesterone, 30 min prior to the first extinction session in freely cycling, heroin-seeking female rats. Although neither treatment produced long-term effects on ...[more]
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