Ontology highlight
ABSTRACT:
SUBMITTER: Rayner E
PROVIDER: S-EPMC6919265 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Rayner Emily E Durin Mary-Anne MA Thomas Rachael R Moralli Daniela D O'Cathail Sean M SM Tomlinson Ian I Green Catherine M CM Lewis Annabelle A
The CRISPR journal 20191119 6
CRISPR-Cas9 has quickly become the method of choice for genome editing, with multiple publications describing technical advances and novel applications. It has been widely adopted as a tool for basic research and has significant translational and clinical potential. However, its usage has outpaced the establishment of essential and rigorous controls for unwanted off-target effects, manifested as small mutations, large deletions of target loci, or large-scale chromosomal rearrangements. A common ...[more]