Dataset Information

Is sleep disturbance linked to short- and long-term outcomes following treatments for recurrent depression?

ABSTRACT:

Background

Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear.

Methods

We assessed sleep disturbance repeatedly in: a) 523 adults with recurrent MDD who consented to 12-14 weeks of acute-phase cognitive therapy (A-CT) and b) 241 A-CT responders at elevated risk for depression relapse/recurrence who were randomized to 8 months of continuation-phase treatment (CCT vs. fluoxetine vs. matched pill placebo) and followed protocol-treatment-free for 24 months. Trajectories of change in sleep and depression during and after A-CT were evaluated with multilevel models; individual intercepts and slopes were retained and input into Cox regression models to predict remission, recovery, relapse, and recurrence of MDD.

Results

Sleep disturbance improved over the course of A-CT, but most patients continued to report clinically significant sleep complaints. Response and remission were more likely in patients with less overall sleep disturbance and those with greater reduction in sleep disturbance during A-CT; these patients also achieved post-A-CT remission and recovery sooner. Sleep improvements endured throughout follow-up but were not enhanced by continuation-phase treatment. Sleep disturbance did not predict relapse or recurrence consistently.

Limitations

Objective sleep disturbance was not assessed. Analyses were not specifically powered to use sleep changes to predict outcomes.

Conclusions

Improvements in sleep disturbance during A-CT are linked to shorter times to remission and recovery, supporting consideration of monitoring and targeting sleep disturbance in adults with depression.

SUBMITTER: Boland EM

PROVIDER: S-EPMC6919563 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Is sleep disturbance linked to short- and long-term outcomes following treatments for recurrent depression?

Boland Elaine M EM Vittengl Jeffrey R JR Clark Lee Anna LA Thase Michael E ME Jarrett Robin B RB

Journal of affective disorders 20191031

<h4>Background</h4>Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear.<h4>Methods</h4>We assessed sleep disturbance repeatedly in: a) 523 adults with recurrent MDD who consented to 12-14 weeks of acute-phase cognitive therapy (A-CT) and b) 241 A-CT responders at elevated risk for depr ...[more]

PMID: 31735410

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Dataset Information

Is sleep disturbance linked to short- and long-term outcomes following treatments for recurrent depression?

Background

Methods

Results

Limitations

Conclusions

Publications

Is sleep disturbance linked to short- and long-term outcomes following treatments for recurrent depression?

Similar Datasets

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