Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.
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ABSTRACT:
SUBMITTER: Mills BN
PROVIDER: S-EPMC6919969 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.
Mills Bradley N BN Connolly Kelli A KA Ye Jian J Murphy Joseph D JD Uccello Taylor P TP Han Booyeon J BJ Zhao Tony T Drage Michael G MG Murthy Aditi A Qiu Haoming H Patel Ankit A Figueroa Nathania M NM Johnston Carl J CJ Prieto Peter A PA Egilmez Nejat K NK Belt Brian A BA Lord Edith M EM Linehan David C DC Gerber Scott A SA
Cell reports 20191001 2
Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating PDA, and here, we report that its combination with local interleukin-12 (IL-12) microsphere (MS) immunotherapy results in marked tumor reduction and cures in multiple preclinical mouse models of PDA. Our findings demonstrate an incre ...[more]
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