Ontology highlight
ABSTRACT:
SUBMITTER: Gassen NC
PROVIDER: S-EPMC6920372 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Gassen Nils C NC Niemeyer Daniela D Muth Doreen D Corman Victor M VM Martinelli Silvia S Gassen Alwine A Hafner Kathrin K Papies Jan J Mösbauer Kirstin K Zellner Andreas A Zannas Anthony S AS Herrmann Alexander A Holsboer Florian F Brack-Werner Ruth R Boshart Michael M Müller-Myhsok Bertram B Drosten Christian C Müller Marcel A MA Rein Theo T
Nature communications 20191218 1
Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitination of BECN1, thus promoting its proteasomal degradation. SKP2 activity is regulated by phosphorylation in a hetero-complex involving FKBP51, PHLPP, AKT1, and BECN1. Genetic or pharmacological inhibition of SKP2 decreases BECN1 ubiquitina ...[more]