Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC6920777 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Lee Jaeok J Chae Song Wha SW Ma LianJi L Lim So Yeon SY Alnajjar Sarah S Park Choo Hea-Young HY Lee Hwa Jeong HJ Rhie Sandy Jeong SJ
Pharmaceutics 20191109 11
P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound <b>5c</b>, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUC<sub>inf</sub> ...[more]