Unknown

Dataset Information

0

Clearance of Staphylococcus aureus from In Vivo Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens.


ABSTRACT: Staphylococcus aureus is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-embedded bacterial populations. However, the addition of antibiotics was required to eradicate remaining planktonic populations. In this study, a planktonic upregulated antigen was combined with the quadrivalent vaccine to remove the need for antibiotic therapy. Immunization with this pentavalent vaccine followed by intraperitoneal challenge of BALB/c mice with S. aureus resulted in 16.7% and 91.7% mortality in pentavalent vaccine and control groups, respectively (P?

SUBMITTER: Harro JM 

PROVIDER: S-EPMC6921670 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Clearance of Staphylococcus aureus from <i>In Vivo</i> Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens.

Harro Janette M JM   Achermann Yvonne Y   Freiberg Jeffrey A JA   Allison Devon L DL   Brao Kristen J KJ   Marinos Dimitrius P DP   Sanjari Salar S   Leid Jeff G JG   Shirtliff Mark E ME  

Infection and immunity 20191217 1


<i>Staphylococcus aureus</i> is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-embedded bacterial populations. However, the addition of antibiotics was required to eradicate remaining planktonic population  ...[more]

Similar Datasets

2021-10-18 | GSE185864 | GEO
| S-EPMC6021908 | biostudies-other
| S-EPMC6274806 | biostudies-literature
| S-EPMC6013659 | biostudies-literature
| S-EPMC5773577 | biostudies-literature
| S-EPMC7080272 | biostudies-literature
| S-EPMC6467803 | biostudies-literature
| S-EPMC5220359 | biostudies-literature
2011-08-31 | GSE24370 | GEO
2011-08-31 | GSE24118 | GEO