Ontology highlight
ABSTRACT:
SUBMITTER: Harro JM
PROVIDER: S-EPMC6921670 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Harro Janette M JM Achermann Yvonne Y Freiberg Jeffrey A JA Allison Devon L DL Brao Kristen J KJ Marinos Dimitrius P DP Sanjari Salar S Leid Jeff G JG Shirtliff Mark E ME
Infection and immunity 20191217 1
<i>Staphylococcus aureus</i> is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-embedded bacterial populations. However, the addition of antibiotics was required to eradicate remaining planktonic population ...[more]