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Clearance of Staphylococcus aureus from In Vivo Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens.


ABSTRACT: Staphylococcus aureus is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-embedded bacterial populations. However, the addition of antibiotics was required to eradicate remaining planktonic populations. In this study, a planktonic upregulated antigen was combined with the quadrivalent vaccine to remove the need for antibiotic therapy. Immunization with this pentavalent vaccine followed by intraperitoneal challenge of BALB/c mice with S. aureus resulted in 16.7% and 91.7% mortality in pentavalent vaccine and control groups, respectively (P?

SUBMITTER: Harro JM 

PROVIDER: S-EPMC6921670 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Clearance of Staphylococcus aureus from <i>In Vivo</i> Models of Chronic Infection by Immunization Requires Both Planktonic and Biofilm Antigens.

Harro Janette M JM   Achermann Yvonne Y   Freiberg Jeffrey A JA   Allison Devon L DL   Brao Kristen J KJ   Marinos Dimitrius P DP   Sanjari Salar S   Leid Jeff G JG   Shirtliff Mark E ME  

Infection and immunity 20191217 1


<i>Staphylococcus aureus</i> is a causative agent of chronic biofilm-associated infections that are recalcitrant to resolution by the immune system or antibiotics. To combat these infections, an antistaphylococcal, biofilm-specific quadrivalent vaccine against an osteomyelitis model in rabbits has previously been developed and shown to be effective at eliminating biofilm-embedded bacterial populations. However, the addition of antibiotics was required to eradicate remaining planktonic population  ...[more]

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