Ontology highlight
ABSTRACT:
SUBMITTER: Shin JD
PROVIDER: S-EPMC6923537 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Shin Justin D JD Tang Wenbo W Jadhav Shantanu P SP
Neuron 20191030 6
Spatial learning requires remembering and choosing paths to goals. Hippocampal place cells replay spatial paths during immobility in reverse and forward order, offering a potential mechanism. However, how replay supports both goal-directed learning and memory-guided decision making is unclear. We therefore continuously tracked awake replay in the same hippocampal-prefrontal ensembles throughout learning of a spatial alternation task. We found that, during pauses between behavioral trajectories, ...[more]