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Bidirectional prefrontal-hippocampal interactions support context-guided memory.

ABSTRACT: We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.

SUBMITTER: Place R

PROVIDER: S-EPMC4961615 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Bidirectional prefrontal-hippocampal interactions support context-guided memory.

Place Ryan R Farovik Anja A Brockmann Marco M Eichenbaum Howard H

Nature neuroscience 20160620 8

We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory ...[more]

PMID: 27322417

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