Evaluation of the increased risk of spine fracture in patients with mood disorder compared with matched controls: a longitudinal follow-up study using a national sample cohort in Korea.

ABSTRACT: OBJECTIVE:To evaluate the risk of spine fracture in patients with mood disorder using a nationwide cohort. DESIGN:A longitudinal follow-up study. SETTING:Claims data for the population ?20 years of age were collected from 2002 to 2013 for the Korean National Health Insurance Service-National Sample Cohort. PARTICIPANTS:A total of 60?140 individuals with mood disorder were matched with 240?560 individuals (control group) for age, sex, income, region of residence and osteoporosis. INTERVENTIONS:In both the mood disorder and control groups, the history of spine fracture was evaluated. The International Classification of Diseases 10th Revision codes for mood disorder (F31-F39) and spine fracture (S220 and S320) were included. PRIMARY AND SECONDARY OUTCOME MEASURES:The univariable and multivariable HRs and 95% CIs of spine fracture for patients with mood disorder were analysed using a stratified Cox proportional hazards model. Subgroup analyses were conducted according to the history of osteoporosis, age and sex. RESULTS:Approximately 3.3% (2011/60 140) of patients in the mood disorder group and 2.8% (6795/240 560) of individuals in the control group had spine fracture (p<0.001). The mood disorder group demonstrated a higher adjusted HR for spine fracture than the control group (multivariable HR=1.10, 95%?CI 1.04 to 1.15, p<0.001). The participants without osteoporosis showed a higher HR of mood disorder for spine fracture than the control participants (multivariable HR=1.25, 95%?CI 1.14 to 1.37, p<0.001). According to age and sex, this result was consistent in subgroups of women aged 20-39 and 40-59 years and men aged ?60 years. CONCLUSION:The risk of spine fracture was increased in patients with mood disorder. The potential risk of spine fracture needs to be evaluated when managing patients with mood disorder.

SUBMITTER: Kim SY 

PROVIDER: S-EPMC6924799 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature