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Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.

ABSTRACT: Aim: To investigate the relation between polymorphisms in the interleukin 10 (IL)-10, tumor necrosis factor (TNF)-?, transforming growth factor (TGF)-? and interferon (IFN)-? genes and Takayasu's arteritis in the Mexican population. Methods: A case-control study was performed to investigate the associations of IL-10, TNF-?, TGF-? and IFN-? polymorphisms in a sample of 52 Takayasu's arteritis patients, diagnosed according to the criteria of the American College of Rheumatology and EULAR PRINTO criteria when the patients were under 18 years of age; 60 clinically healthy unrelated Mexican individuals by the 5' exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. Results: Significant differences were not found in the distribution for genotype and allele frequencies of the polymorphisms studied between healthy controls and Takayasu´s arteritis patients. Likewise, significant associations were not detected in the haplotype analysis with the different genes studied. Conclusions: These findings suggest that the polymorphisms in IL-10, TNF-?, TGF-? and IFN-? might not contribute to the susceptibility of Takayasu´s arteritis in the Mexican population.

SUBMITTER: Soto ME 

PROVIDER: S-EPMC6926720 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.

Soto María Elena ME   Huesca-Gómez Claudia C   Torres-Paz Yazmín Y   Fuentevilla-Álvarez Giovanny G   Gamboa Ricardo R  

International journal of environmental research and public health 20191203 23

<i>Aim</i>: To investigate the relation between polymorphisms in the interleukin 10 (<i>IL</i>)-<i>10</i>, tumor necrosis factor (<i>TNF)</i>-α, transforming growth factor (<i>TGF)-</i>β and interferon (<i>IFN)-γ</i> genes and Takayasu's arteritis in the Mexican population. <i>Methods</i>: A case-control study was performed to investigate the associations of <i>IL-10</i>, <i>TNF-α</i>, <i>TGF-β</i> and <i>IFN-γ</i> polymorphisms in a sample of 52 Takayasu's arteritis patients, diagnosed accordin  ...[more]

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