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Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents.

ABSTRACT: Efficient HIV-1 transduction depends on a number of cellular co-factors. Cellular double-strand DNA break (DSB) repair proteins have been proposed, by ourselves and others, to be required for efficient HIV-1 transduction. Expression and/or activity of these DNA repair proteins can be induced by the introduction of DSBs into the host cell genome. HIV-1 transduction was up-regulated by treatment with DSB-inducing agents in both drug-arrested cells and differentiated neuronal cells. The presented data support the hypothesis that DSB repair proteins are involved in the early steps of the retroviral life-cycle.

SUBMITTER: Smith JA

PROVIDER: S-EPMC6927543 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents.

Smith Johanna A JA Daniel René R

Biotechnology letters 20101024 2

Efficient HIV-1 transduction depends on a number of cellular co-factors. Cellular double-strand DNA break (DSB) repair proteins have been proposed, by ourselves and others, to be required for efficient HIV-1 transduction. Expression and/or activity of these DNA repair proteins can be induced by the introduction of DSBs into the host cell genome. HIV-1 transduction was up-regulated by treatment with DSB-inducing agents in both drug-arrested cells and differentiated neuronal cells. The presented d ...[more]

PMID: 20972817

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