Ontology highlight
ABSTRACT:
SUBMITTER: Vijayaraj P
PROVIDER: S-EPMC6927560 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Vijayaraj Preethi P Minasyan Aspram A Durra Abdo A Karumbayaram Saravanan S Mehrabi Mehrsa M Aros Cody J CJ Ahadome Sarah D SD Shia David W DW Chung Katherine K Sandlin Jenna M JM Darmawan Kelly F KF Bhatt Kush V KV Manze Chase C CC Paul Manash K MK Wilkinson Dan C DC Yan Weihong W Clark Amander T AT Rickabaugh Tammy M TM Wallace W Dean WD Graeber Thomas G TG Damoiseaux Robert R Gomperts Brigitte N BN
Cell reports 20191201 11
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares common cellular and molecular pathways involving chronic injury, inflammation, and aberrant repair resulting in deposition of extracellular matrix, organ remodeling, and ultimately organ failure. We describe the generation and characterization o ...[more]