Ontology highlight
ABSTRACT:
SUBMITTER: Lee E
PROVIDER: S-EPMC6927645 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
PloS one 20191223 12
Krabbe disease, also known as globoid cell leukodystrophy, is a rare genetic neurodegenerative disease caused by a deficiency of the galactocerebrosidase enzyme. To understand the association status of human beta-galactocerebrosidase (hGALC) in solution, we employed analytical ultracentrifugation (AUC). Our AUC results show that hGALC has a tendency for reversible self-association. Self-association decreases as the concentration of sodium chloride increases from 50 to 500 mM. This indicates that ...[more]