Dataset Information

HIF-1? promotes the keloid development through the activation of TGF-?/Smad and TLR4/MyD88/NF-?B pathways.

ABSTRACT: A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1? (HIF-1?) is a core factor that mediates hypoxia stress responses and regulates the hypoxic cellular and biological behaviors. In this study, we found that the expression level of HIF-1? in keloid tissue was significantly higher than that in the normal skin tissue. Hypoxia-induced HIF-1? expression significantly inhibited cellular apoptosis and promoted cellular proliferation in keloid fibroblasts but not in normal fibroblasts. Specifically, HIF-1? activated the TGF-?/Smad and TLR4/MyD88/NF-?B pathways, and the interaction of these two pathways may promote the development of keloids. Moreover, in vivo experiments showed that the inhibition of HIF-1? significantly reduced the growth of keloids.

SUBMITTER: Lei R

PROVIDER: S-EPMC6927730 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.

Lei Rui R Li Jian J Liu Feng F Li Weihan W Zhang Shizhen S Wang Yang Y Chu Xi X Xu Jinghong J

Cell cycle (Georgetown, Tex.) 20191023 23

A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic cellular and biological behaviors. In this study, we found that the expression level of HIF-1α in keloid tissue was significantly higher than that in the normal skin tissue. Hypoxia-induced HIF-1α exp ...[more]

PMID: 31645185

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Dataset Information

HIF-1? promotes the keloid development through the activation of TGF-?/Smad and TLR4/MyD88/NF-?B pathways.

Publications

HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.

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