Ontology highlight
ABSTRACT:
SUBMITTER: Kondoh T
PROVIDER: S-EPMC6927862 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kondoh Tatsunari T Letko Michael M Munster Vincent J VJ Manzoor Rashid R Maruyama Junki J Furuyama Wakako W Miyamoto Hiroko H Shigeno Asako A Fujikura Daisuke D Takadate Yoshihiro Y Yoshida Reiko R Igarashi Manabu M Feldmann Heinz H Marzi Andrea A Takada Ayato A
The Journal of infectious diseases 20181101 suppl_5
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. It is known that proteolytically digested Ebola virus (EBOV) GP interacts with 2 protruding loops in domain C of NPC1. Using previously published structural data and the National Center for Biotechnology Information Single-Nucleotide Polymorphism (SNP) database, we identified 10 naturally ...[more]