Ontology highlight
ABSTRACT:
SUBMITTER: Gluexam T
PROVIDER: S-EPMC6928760 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Gluexam Tobias T Grandits Alexander M AM Schlerka Angela A Nguyen Chi Huu CH Etzler Julia J Finkes Thomas T Fuchs Michael M Scheid Christoph C Heller Gerwin G Hackl Hubert H Harrer Nathalie N Sill Heinz H Koller Elisabeth E Stoiber Dagmar D Sommergruber Wolfgang W Wieser Rotraud R
International journal of molecular sciences 20191120 23
The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. Recently, high <i>CALCRL</i> expression has been shown to be associated with a poor prognosis in acute myeloid leukemia (AML). We investigate, therefore, the functional role of the CGRP-CALCRL axis in AML. To this end, <i>in silico</i> analyses, human AML cell lines, primary patient samples, ...[more]