Dataset Information

Preterm birth and risk of sleep-disordered breathing from childhood into mid-adulthood.

ABSTRACT: BACKGROUND:Preterm birth (gestational age <37?weeks) has previously been associated with cardiometabolic and neuropsychiatric disorders into adulthood, but has seldom been examined in relation to sleep disorders. We conducted the first population-based study of preterm birth in relation to sleep-disordered breathing (SDB) from childhood into mid-adulthood. METHODS:A national cohort study was conducted of all 4 186 615 singleton live births in Sweden during 1973-2014, who were followed for SDB ascertained from nationwide inpatient and outpatient diagnoses through 2015 (maximum age 43?years). Cox regression was used to examine gestational age at birth in relation to SDB while adjusting for other perinatal and maternal factors, and co-sibling analyses assessed for potential confounding by unmeasured shared familial factors. RESULTS:There were 171 100 (4.1%) persons diagnosed with SDB in 86.0 million person-years of follow-up. Preterm birth was associated with increased risk of SDB from childhood into mid-adulthood, relative to full-term birth (39-41?weeks) [adjusted hazard ratio (aHR), ages 0-43?years: 1.43; 95% confidence interval (CI), 1.40, 1.46; P?<0.001; ages 30-43?years: 1.40; 95% CI, 1.34, 1.47; P?<0.001]. Persons born extremely preterm (<28?weeks) had more than 2-fold risks (aHR, ages 0-43?years: 2.63; 95% CI, 2.41, 2.87; P?<0.001; ages 30-43?years: 2.22; 95% CI, 1.64, 3.01; P?<0.001). These associations affected both males and females, but accounted for more SDB cases among males (additive interaction, P?=?0.003). Co-sibling analyses suggested that these findings were only partly due to shared genetic or environmental factors in families. CONCLUSIONS:Preterm-born children and adults need long-term follow-up for anticipatory screening and potential treatment of SDB.

SUBMITTER: Crump C

PROVIDER: S-EPMC6929528 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Preterm birth and risk of sleep-disordered breathing from childhood into mid-adulthood.

Crump Casey C Friberg Danielle D Li Xinjun X Sundquist Jan J Sundquist Kristina K

International journal of epidemiology 20191201 6

<h4>Background</h4>Preterm birth (gestational age <37 weeks) has previously been associated with cardiometabolic and neuropsychiatric disorders into adulthood, but has seldom been examined in relation to sleep disorders. We conducted the first population-based study of preterm birth in relation to sleep-disordered breathing (SDB) from childhood into mid-adulthood.<h4>Methods</h4>A national cohort study was conducted of all 4 186 615 singleton live births in Sweden during 1973-2014, who were foll ...[more]

PMID: 31006012

Similar Datasets

Project description:ObjectiveTo examine the association between sleep-disordered breathing and stroke outcomes, and determine the contribution of sleep-disordered breathing to outcome disparities in Mexican Americans.MethodsIschemic stroke patients (n = 995), identified from the population-based Brain Attack Surveillance in Corpus Christi Project (2010-2015), were offered participation in a sleep-disordered breathing study including a home sleep apnea test (ApneaLink Plus). Sleep-disordered breathing (respiratory event index ≥10) was determined soon after stroke. Neurologic, functional, cognitive, and quality of life outcomes were assessed at 90 days poststroke. Regression models were used to assess associations between sleep-disordered breathing and outcomes, adjusted for sociodemographics, prestroke function and cognition, health-risk behaviors, stroke severity, and vascular risk factors.ResultsMedian age was 67 years (interquartile range [IQR] = 59-78); 62.1% were Mexican American. Median respiratory event index was 14 (IQR = 6-25); 62.8% had sleep-disordered breathing. Sleep-disordered breathing was associated with worse functional outcome (mean difference in activities of daily living/instrumental activities of daily living score = 0.15, 95% confidence interval [CI] = 0.01-0.28) and cognitive outcome (mean difference in modified Mini-Mental State Examination = -2.66, 95% CI = -4.85 to -0.47) but not neurologic or quality of life outcomes. Sleep-disordered breathing accounted for 9 to 10% of ethnic differences in functional and cognitive outcome and was associated with cognitive outcome more strongly for Mexican Americans (β = -3.97, 95% CI = -6.63 to -1.31) than non-Hispanic whites (β = -0.40, 95% CI = -4.18 to 3.39, p-interaction = 0.15).InterpretationSleep-disordered breathing is associated with worse functional and cognitive function at 90 days poststroke. These outcomes are reasonable endpoints for future trials of sleep-disordered breathing treatment in stroke. If effective, sleep-disordered breathing treatment may somewhat lessen ethnic stroke outcome disparities. ANN NEUROL 2019;86:241-250.

Dataset Information

Preterm birth and risk of sleep-disordered breathing from childhood into mid-adulthood.

Publications

Preterm birth and risk of sleep-disordered breathing from childhood into mid-adulthood.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets