Ontology highlight
ABSTRACT:
SUBMITTER: Bucko PJ
PROVIDER: S-EPMC6930117 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
eLife 20191224
Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. We exploited the AKAP targeting concept to create genetically encoded platforms that restrain kinase inhibitor drugs at distinct subcellular locations. <b><u>Lo</u></b>cal <b><u>K</u></b>inase <b><u>I</u></b>nhibition (<b>LoKI</b>) allows us to ascrib ...[more]