Ontology highlight
ABSTRACT:
SUBMITTER: Smith FD
PROVIDER: S-EPMC5693252 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170601 6344
Hormones can transmit signals through adenosine 3',5'-monophosphate (cAMP) to precise intracellular locations. The fidelity of these responses relies on the activation of localized protein kinase A (PKA) holoenzymes. Association of PKA regulatory type II (RII) subunits with A-kinase-anchoring proteins (AKAPs) confers location, and catalytic (C) subunits phosphorylate substrates. Single-particle electron microscopy demonstrated that AKAP79 constrains RII-C subassemblies within 150 to 250 angstrom ...[more]