Dataset Information

Automated Quantification of Macular Ellipsoid Zone Intensity in Glaucoma Patients: the Method and its Comparison with Manual Quantification.

ABSTRACT: The macular ellipsoid zone intensity (mEZi) is a known marker of disease severity in a number of diverse ocular diseases. The purpose of this study was to establish an automated method (AM) for mEZi quantification and to compare the method's performance with that of a manual method (MM) for glaucoma patients and healthy controls. Seventy-one (71) mild-to-moderate glaucoma patients, 71 severe-glaucoma patients, and 51 controls were enrolled. Both calibration (n?=?160) and validation (n?=?33) image sets were compiled. The correlation of AM to MM quantification was assessed by Deming regression for the calibration set, and a compensation formula was generated. Then, for each image in the validation set, the compensated AM quantification was compared with the mean of five repetitive MM quantifications. The AM quantification of the calibration set was found to be linearly correlated with MM in the normal-to-severe-stage glaucoma patients (R2?=?0.914). The validation set's compensated AM quantification produced R2?=?0.991, and the relationship between the 2 quantifications was AM?=?1.004(MM)?+?0.139. In the validation set, the compensated AM quantification fell within MM quantification's 95% confidence interval in 96.9% of the images. An AM for mEZi quantification was calibrated and validated relative to MM quantification for both glaucoma patients and healthy controls.

SUBMITTER: Ha A

PROVIDER: S-EPMC6930206 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Automated Quantification of Macular Ellipsoid Zone Intensity in Glaucoma Patients: the Method and its Comparison with Manual Quantification.

Ha Ahnul A Sun Sukkyu S Kim Young Kook YK Jeoung Jin Wook JW Kim Hee Chan HC Park Ki Ho KH

Scientific reports 20191224 1

The macular ellipsoid zone intensity (mEZi) is a known marker of disease severity in a number of diverse ocular diseases. The purpose of this study was to establish an automated method (AM) for mEZi quantification and to compare the method's performance with that of a manual method (MM) for glaucoma patients and healthy controls. Seventy-one (71) mild-to-moderate glaucoma patients, 71 severe-glaucoma patients, and 51 controls were enrolled. Both calibration (n = 160) and validation (n = 33) imag ...[more]

PMID: 31875050

Similar Datasets

Project description:New methods are needed to quantify the change in the outer retinal structures in retinitis pigmentosa (RP).To implement an alternate method for tracking ellipsoid zone (EZ) changes in RP by quantifying the EZ area on en face spectral domain-optical coherence tomographic (SD-OCT) images.Data for this observational case study were collected at the Department of Ophthalmology, University of California, Los Angeles, from May 1 to July 30, 2015, and included SD-OCT images of a subset of patients from the Trial of Oral Valproic Acid for Retinitis Pigmentosa. To be eligible for the en face OCT subanalysis, the preserved EZ area was required to be limited to the SD-OCT scanning field. Cases in which the EZ band extended to the margins of any B-scan or the most superior or inferior B-scan were excluded. The SD-OCT images of all included cases were imported into the manufacturer's software to generate en face images at the level of the EZ. Two certified SD-OCT graders independently delineated the boundaries of the preserved EZ on the en face images.Comparison of the 2 masked gradings of the generated en face images of patients with RP for agreement between the graders and the validity of the method.Of the 43 available patients with volume SD-OCT data, 45 eyes of 24 patients met the eligibility criteria and were included in this subanalysis. Every patient had 2 visits that were 1 year apart, which included a total of 90 en face OCT images that were graded. The mean (SD) absolute difference and percentage difference between the 2 independent graders for each visit were 0.08 (0.10) mm2 and 4.5% (5.9%), respectively. The EZ area determined by the 2 graders showed excellent agreement with an intraclass correlation coefficient of 0.996 (95% CI, 0.995-0.997; P?<?.001).Quantification of the preserved EZ area on en face SD-OCT images of patients with RP is a valid and reproducible method. En face SD-OCT quantification may be a useful tool for monitoring the EZ changes of patients with advanced RP and a useful outcome measurement variable in therapeutic trials.

Dataset Information

Automated Quantification of Macular Ellipsoid Zone Intensity in Glaucoma Patients: the Method and its Comparison with Manual Quantification.

Publications

Automated Quantification of Macular Ellipsoid Zone Intensity in Glaucoma Patients: the Method and its Comparison with Manual Quantification.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets