Ontology highlight
ABSTRACT:
SUBMITTER: Vian L
PROVIDER: S-EPMC6930870 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Vian Laura L Le Mimi T MT Gazaniga Nathalia N Kieltyka Jacqueline J Liu Christine C Pietropaolo Giuseppe G Dell'Orso Stefania S Brooks Stephen R SR Furumoto Yasuko Y Thomas Craig J CJ O'Shea John J JJ Sciumè Giuseppe G Gadina Massimo M
Frontiers in immunology 20191219
Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have revealed major alterations on natural killer (NK) cell homeostasis associated with JAK inhibitions, while information on other innate lymphoid cells (ILCs) is still lacking. Herein, we observed that, in mice, the homeostatic pool of liver ILC1 was less affected by JAK inhibitors compared to the pool of NK cells present in the liver, spleen ...[more]