Dataset Information

A Novel Weight Lifting Task for Investigating Effort and Persistence in Rats.

ABSTRACT: Here we present a novel effort-based task for laboratory rats: the weight lifting task (WLT). Studies of effort expenditure in rodents have typically involved climbing barriers within T-mazes or operant lever pressing paradigms. These task designs have been successful for neuropharmacological and neurophysiological investigations, but both tasks involve simple action patterns. High climbing barriers may also present risk of injury to animals and/or issues with tethered recording equipment. In the WLT, a rat is placed in a large rectangular arena and tasked with pulling a rope 30 cm to trigger food delivery at a nearby spout; weights can be added to the rope in 45 g increments to increase the intensity of effort. As compared to lever pressing and barrier jumping, 30 cm of rope pulling is a multi-step action sequence requiring sustained effort. The actions are carried out on the single plane of the arena floor, making it safer for the animal and more suitable for tethered equipment and video tracking. A microcontroller and associated sensors enable precise timestamping of specific behaviors to synchronize with electrophysiological recordings. The rope and reward spout are spatially segregated to allow for spatial discrimination of the effort zone and the reward zone. We validated the task across five cohorts of rats (total n = 35) and report consistent behavioral metrics. The WLT is well-suited for neuropharmacological and/or in vivo neurophysiological investigations surrounding effortful behaviors, particularly when wanting to probe different aspects of effort expenditure (intensity vs. duration).

SUBMITTER: Porter B

PROVIDER: S-EPMC6930902 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

A Novel Weight Lifting Task for Investigating Effort and Persistence in Rats.

Porter Blake B Hillman Kristin L KL

Frontiers in behavioral neuroscience 20191219

Here we present a novel effort-based task for laboratory rats: the weight lifting task (WLT). Studies of effort expenditure in rodents have typically involved climbing barriers within T-mazes or operant lever pressing paradigms. These task designs have been successful for neuropharmacological and neurophysiological investigations, but both tasks involve simple action patterns. High climbing barriers may also present risk of injury to animals and/or issues with tethered recording equipment. In th ...[more]

PMID: 31920582

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Project description:The aim of this study was to investigate the effect of numeracy and the emotion of fear on the decision-making process. While previous research demonstrated that these factors are independently related to search effort, search policy and choice in a decision from experience task, less is known about how their interaction contributes to processing information under uncertainty. We attempted to address this problem and to fill this gap. In the present study, we hypothesized that more numerate people would sample more information about a decision problem and that the effect of fear would depend on the source of this emotion: whether it is integral (i.e., relevant) or incidental (i.e., irrelevant) to a decision problem. Additionally, we tested how these factors predict choices. We addressed these hypotheses in a series of two experiments. In each experiment, we used a sampling paradigm to measure search effort, search policy and choice in nine binary problems included in a decision from experience task. In Experiment 1, before the sampling task we elicited incidental fear by asking participants to recall fearful events from their life. In Experiment 2, integral fear was elicited by asking participants to make choices concerning medical treatment. Decision problems and their payoff distributions were the same in the two experiments and across each condition. In both experiments, we assessed objective statistical numeracy and controlled for a change in the current emotional state. We found that more numerate people sampled more information about a decision problem and switched less frequently between alternatives. Incidental fear marginally predicted search effort. Integral fear led to larger sample sizes, but only among more numerate people. Neither numeracy nor fear were related to the number of choices that maximized expected values. However, across two experiments sample sizes predicted the number of choices that maximized experienced mean returns. The findings suggest that people with higher numeracy may be more sensitive to integral emotions; this may result in more effortful sampling of relevant information leading to choices maximizing experienced returns.

Project description:Recent research has demonstrated that pupillometry is a robust measure for quantifying listening effort. However, pupillary responses in listening situations where multiple cognitive functions are engaged and sustained over a period of time remain hard to interpret. This limits our conceptualisation and understanding of listening effort in realistic situations, because rarely in everyday life are people challenged by one task at a time. Therefore, the purpose of this experiment was to reveal the dynamics of listening effort in a sustained listening condition using a word repeat and recall task. Words were presented in quiet and speech-shaped noise at different signal-to-noise ratios (SNR): 0dB, 7dB, 14dB and quiet. Participants were presented with lists of 10 words, and required to repeat each word after its presentation. At the end of the list, participants either recalled as many words as possible or moved on to the next list. Simultaneously, their pupil dilation was recorded throughout the whole experiment. When only word repeating was required, peak pupil dilation (PPD) was bigger in 0dB versus other conditions; whereas when recall was required, PPD showed no difference among SNR levels and PPD in 0dB was smaller than repeat-only condition. Baseline pupil diameter and PPD followed different variation patterns across the 10 serial positions within a block for conditions requiring recall: baseline pupil diameter built up progressively and plateaued in the later positions (but shot up when listeners were recalling the previously heard words from memory); PPD decreased at a pace quicker than in repeat-only condition. The current findings demonstrate that additional cognitive load during a speech intelligibility task could disturb the well-established relation between pupillary response and listening effort. Both the magnitude and temporal pattern of task-evoked pupillary response differ greatly in complex listening conditions, urging for more listening effort studies in complex and realistic listening situations.

Dataset Information

A Novel Weight Lifting Task for Investigating Effort and Persistence in Rats.

Publications

A Novel Weight Lifting Task for Investigating Effort and Persistence in Rats.

Similar Datasets

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