Ontology highlight
ABSTRACT:
SUBMITTER: da Silva RAG
PROVIDER: S-EPMC6930937 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
da Silva Ronni A G RAG Karlyshev Andrey V AV Oldfield Neil J NJ Wooldridge Karl G KG Bayliss Christopher D CD Ryan Ali A Griffin Ruth R
Frontiers in microbiology 20191219
Meningococcal lipoprotein, Factor H binding protein (FHbp), is the sole antigen of the Trumenba vaccine (Pfizer) and one of four antigens of the Bexsero vaccine (GSK) targeting <i>Neisseria meningitidis</i> serogroup B isolates. Lipidation of FHbp is assumed to occur for all isolates. We show in the majority of a collection of United Kingdom isolates (1742/1895) non-synonymous single nucleotide polymorphisms (SNPs) in the signal peptide (SP) of FHbp. A single SNP, common to all, alters a polar a ...[more]